石川県金沢市松村の内科、肝臓・内視鏡・消化器内科、糖尿病・代謝・内分泌内科
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院長・副院長の勤務医時代の業績集

これまでの院長の業績：（金沢大学第一内科、ガンセンター）

1. Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma.
Cancer Gene Ther. 2012 Mar 9.doi: 10.1038/cgt.2012.3. Marukawa Y, Nakamoto Y, Kakinoki K, ★Tsuchiyama T, Iida N, Kagaya T, Sakai Y, Naito M, Mukaida N, Kaneko S.

2. Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice. J Gene Med. 2010 Dec;12(12):1002-13. Kakinoki K, Nakamoto Y, Kagaya T, ★Tsuchiyama T, Sakai Y, Nakahama T, Mukaida N, Kaneko S.

3. Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy. J Infect Chemother. 2009 Oct;15(5):316-21. Epub 2009 Oct 24. Ohtsubo K, Watanabe H, ★Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Okai T, Sanada J, Matsui O, Kitamura T, Fujiki R, Tokuuye K, Sawabu N.

4. Cancer of unknown primary site in which tumor marker-oriented chemotherapy was effective and pancreatic cancer was finally confirmed at autopsy. Intern Med. 2009;48(18):1651-6. Epub 2009 Sep 15. Ohtsubo K, Watanabe H, Yamada T, ★Tsuchiyama T, Mouri H, Yamashita K, Yasumoto K, Ikeda H, Nakanuma Y, Yano S.

5. Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy against hepatocellular carcinoma by M1 macrophage activation. Cancer Sci. 2008 Oct;99(10):2075-82. ★Tsuchiyama T, Nakamoto Y, Sakai Y, Mukaida N, Kaneko S.

6. An autopsy case of pancreatic cancer with poor performance status due to peritonitis carcinomatosa treated successfully with continuous infusion of low-dose 5-FU with octreotide. Nippon Shokakibyo Gakkai Zasshi. 2008 Oct;105(10):1529-35. Japanese. Mouri H, ★Tsuchiyama T, Ohtsubo K, Kayahara M, Ohta T, Kitagawa S, Minato H, Watanabe H.

7. A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice. JOP. 2008 Jan 8;9(1):37-45. Otsubo K, Watanabe H, Okada G, ★Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Okai T, Amaya K, Kitagawa H, Ohta T, Gabata T, Matsuda K, Ohta H, Sawabu N.

8. A case of autoimmune pancreatitis associated with retroperitoneal fibrosis. JOP. 2007 May 9;8(3):320-5. Otsubo K, Watanabe H, ★Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Ohnishi I, Gabata T, Sawabu N.

9. Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma. J Immunol. 2007 Jan 1;178(1):574-83. ★Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, Kaneko S.

10. Diagnostic utility of aberrant methylation of tissue factor pathway inhibitor 2 in pure pancreatic juice for pancreatic carcinoma. Cancer Sci. 2006 Nov;97(11):1267-73. Jiang P, Watanabe H, Okada G, Otsubo K, Mouri H, ★Tsuchiyama T, Yao F, Sawabu N.

11. Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer. Cancer Gene Ther. 2006 Apr;13(4):357-66. Kagaya T, Nakamoto Y, Sakai Y, ★Tsuchiyama T, Yagita H, Mukaida N, Kaneko S.

12. Enhanced anti-tumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma. Cancer Gene Ther. 2003 Apr;10(4):260-9. ★Tsuchiyama T, Kaneko S, Nakamoto Y, Sakai Y, Honda M, Mukaida N, Kobayashi K.

13. Tiny staining spots in liver cirrhosis associated with HCV infection observed by computed tomographic hepatic arteriography (CT-A): follow-up study. J Gastroenterol. 2002;37(10):807-14. ★Tsuchiyama T, Terasaki S, Kaneko S, Kaji K, Kobayashi K, Matsui O.

14. Improvement of hepatic protoporphyrin accumulation after antibiotic treatment. Dig Dis Sci. 2000 Dec;45(12):2411-3. ★Tsuchiyama T, Kaneko S, Matsushita E, Maeda N, Horie Y, Kobayashi K.

15. [Identical female twins diagnosed with type Ia glycogen storage disease in adulthood] Nippon Naika Gakkai Zasshi. 2000 May 10;89(5):986-8. Japanese. Ando H, Hisada Y, ★Tsuchiyama T, Yamashita T, Yamaguro T, Shimoda A, Nishimura Y, Iwata A, Osada S.

16. [Evaluation of modified rapid urease test (MR urea S) in diagnosis of Helicobacter pylori (HP)] Nippon Shokakibyo Gakkai Zasshi. 1997 Oct;94(10):718. Japanese. ★Tsuchiyama T, Shimazaki T, Takemori Y, Noda H.

副院長の業績：（金沢大学第一内科）

1. Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes. Diabetes Care. 2007 Oct;30(10):2583-7. Epub 2007 Jul 20. ★Tsuchiyama N, Takamura T, Ando H, Sakurai M, Shimizu A, Kato K, Kurita S, Kaneko S.

2. Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes. Diabetes Res Clin Pract. 2007 Mar;75(3):278-84. Epub 2006 Oct 27. Takamura T, Sakurai M, Nakamura M, Shimizu A, Ota T, Misu H, Takeshita Y, ★Tsuchiyama N, Kurita S, Ando H, Kaneko S.

3. Modulating effects of olanzapine on the development of diabetic ketoacidosis. Diabet Med. 2004 Mar;21(3):300-1. ★Tsuchiyama N, Ando H, Ota T, Sakurai M, Takamura T.

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